A Most Multi-talented Nerve

MECP2, a multi-talented modulator of chromatin architecture.

It has been a long trip from 1992, the year of the discovery of MECP2, to the present day. What is surprising is that some of the pivotal roles of MeCP2 were already postulated at that time, such as repression of inappropriate expression from repetitive elements and the regulation of pericentric heterochromatin condensation. However, MeCP2 performs many more functions. MeCP2 is a reader of epig...

Talented Imbeciles

The differential diagnosis of the type of feeblemindedness known as imbecility is by no means an artisan's job. No foot rule, scale, or point system has been devised or will ever be devised that will relieve the clinician of long, patient, and discriminating analysis in arriving at a diagnosis. An individual may be diagnosed or classified as an imbecile on the mental scale, on the intellectual ...

The highly talented child.

either before or during the period of immunosuppression does not necessarily confer protection. This is illustrated by two of our patients. Case reports Case 1. A boy, aged 3 years 5 months, first presented with a history of a progressive petechial rash. Physical examination showed pallor, bruising, and hepatosplenomegaly. A bone marrow aspirate confirmed a diagnosis of acute lymphoblastic leuk...

Are most sixth nerve palsies really paralytic?

BACKGROUND Etiology and date of palsy are two important parameters that affect the treatment protocol of sixth nerve palsies. This study evaluated the treatment protocols and outcomes of treatment in sixth nerve palsies. METHODS Thirty-four patients who had sixth nerve palsy were included. Botulinum toxin A (BTX) injection was performed on patients with acute sixth nerve palsy and paresis (BT...

Gifted and talented students